Bone marrow assessment in asymptomatic immunoglobulin M monoclonal gammopathies
نویسندگان
چکیده
منابع مشابه
Immunoglobulin levels and monoclonal gammopathies in children after bone marrow transplantation.
Bone marrow graft recipients suffer profound immunodeficiency during at least 3 months after transplantation. B-cell reconstitution following allogeneic bone marrow transplantation (BMT) in children was studied longitudinally by quantification of Ig (sub)class levels in serum and by investigation of numbers and characteristics of homogeneous Ig components (H-Ig); ie, monoclonal gammopathies (MG...
متن کاملMonoclonal gammopathies
Clinical background The finding of a monoclonal immunoglobulin in the serum defines the so-called monoclonal gammopathy. Monoclonal components are homogeneus immunoglobulins whole (intact) or fragmented, produced by a single expanded plasma cell clone. MCs present unique physicochemical homogeneity, which is reflected in their immunological homogeinity. Immunological homogeinity by electrophore...
متن کاملImportace of monoclonal immunoglobulin in Sjögren’s syndrome
Background: Sjögren’s syndrome is the second most common systemic autoimmune disease after rheumatoid arthritis, RA, with a prevalence of about 0.5% in the general population. It occurs primarily in perimenopausal women (at a ratio of women to men of 9: 1) Sjögren’s syndrome is characterized by lymphocytic infiltration to exocrine glands. The specific autoantibodies of this syndrome are against...
متن کاملAL-amyloidosis in monoclonal gammopathies.
Sixty-two patients affected by MGUS underwent fat tissue aspirate examination for diagnosis of AL amyloidosis. Nine out of the 62 were found to be Congo red positive. MGUS had already been diagnosed for quite a long time in about 60% of these patients, while this prevalence decreased to 24% among the Congo red negative patients. The follow-up of the positive patients is reported.
متن کاملThe monoclonal gammopathies.
Each monoclonal protein (M-protein, or myeloma protein) consists of two heavy polypeptide chains of the same class and subclass and two light polypeptide chains of the same type. Electrophoresis on cellulose acetate membranes is satisfactory for screening, although agarose electrophoresis is more sensitive for detecting small M-proteins. Immunoelectrophoresis should be performed when myeloma, m...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2014
ISSN: 0007-1048
DOI: 10.1111/bjh.13091